Endocrine Abstracts

Subacute thyroiditis (SAT) is a relatively uncommon and self-limited cause of thyrotoxicosis of viral or post-viral origin. During the COVID-19 pandemic a thyroid impact was also considered due to the potential of SARS-CoV-2 virus to cause multiorgan effects. Several SAT cases associated with SARS-CoV-2 infection or vaccination were recently reported in the literature. We present the case of a 52-year-old female who presented with neck pain, fever, asthenia, and malaise for ap...

Hyperprolactinemia is one of the most common problems in clinical endocrinology. It relates with various etiologies (physiological, pharmacological, pathological), the clarification of which requires careful history taking and clinical assessment.We present the case of a 15-year-old girl, with history of secondary amenorrhea and headache in the presence of mildly elevated prolactin level, diagnosed as a microprolactinoma on MRI scan (4–5 mm) and tr...

Primary hypophysitis is a rare inflammatory condition which is mostly encountered in women. It represents 0.2–0.8% of pituitary pathologies and its annual incidence is estimated at 1 case per 9 million inhabitants. We present the case of a 28-year-old male, smoker, with sudden onset decreased libido, polyuria and polydipsia. At presentation he had an epicranial lipoma with and no other suggestive clinical signs. Biochemistry revealed hypernatremia 146 nmol/L, low testoste...

Case presentation: Mrs. S presented in an endocrine clinic for fatigue, weight loss, restlessness and goiter. She was obese with a BMI of 51 kg/mp, hypertensive and had a medium size, nontender goiter. Lab test revealed hyperglycaemia, suppressed TSH (<0.03mUI/L), on two separate occasions, mid-normal fT4 and T3. Thyroid ultrasound revealed multinodular goiter. A diagnosis of polynodular goiter with subclinical hyperthyroidism was made and patient was commenced on thiamazo...

Erdheim-Chester disease (ECD) is a rare histiocytic neoplasm with distinctive clinical and immunophenotypic features, involving somatic mutations of BRAF and activation of MAPK pathway. Other BRAF mutated neoplasms such as papillary thyroid carcinoma (PTC), may also occur synchronous with EDC. There are several reports in the literature of concurrent Langerhans Cell Histiocytosis (LCH) and PTC which suggests that the association is not random, howeve...